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[57] reported that 2-deoxyglucose (2-DG), a glycolytic inhibitor and a caloric restriction mimetic, suppressed the LPS-induced nuclear accumulation of PKM2 and the phosphorylation of STAT3

For example, inhibitors targeting histone demethylases (such as KDM5 inhibitors like CPI-455 or ryuvidine) have demonstrated efficacy in preclinical models by preventing the reversible repression of chromatin states necessary for DTP survival ( 4.2 Exploiting metabolic vulnerabilities of DTP cells Metabolic reprogramming observed in DTP cells provides another therapeutic opportunity