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Bilirubin is a breakdown product of heme, that non-protein part of hemoglobin)

The primary mechanism of action involves the activation of telomerase, an enzyme responsible for maintaining and extending telomeresthe protective caps at the ends of chromosomes

While essential for physiological signaling, excessive NO production in CF airway inflammation can dysregulate S-nitrosylation, contributing to pathology (Kimura, 2020)

The copper ion serves as an essential cofactor for enzymes involved in extracellular matrix maintenance including lysyl oxidase and superoxide dismutase

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