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We previously showed the presence of mitochondrial dysfunction as early as P15 in the motor cortex, but more precisely in the CSMN of TDP-43 A315T mice 17 , one of the best characterized mouse models of TDP-43 pathology 16,19,33,34

Nevertheless, revealing the underlying mechanism of Nrf2 agonists or HO-1 inhibitors in the treatment of PF warrants further investigation

By eliminating the need for manual peptide mixing, it allows researchers to focus entirely on their experiments without the added complexity

They are small, brief and almost constant, and I now realize they are all over my body, not just in my legs

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