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Acute Hypoxia and Ischaemia Studies in older rats examined carotid-artery occlusion or hypoxic exposure and measured behaviour, inflammatory cytokines and caspase-3 activity

5 From 2019 through 2023, Pet Poison Helpline experienced a 735.6% increase in the number of calls regarding pet exposure to THC-containing products.5 THC is a partial agonist at cannabinoid receptor 1 (CB1) and cannabinoid receptor 2 (CB2), endogenous mammalian receptors similar to opioid receptors

doi: 10.1038/ni904 198 BrunkowMEJefferyEWHjerrildKAPaeperBClarkLBYasaykoS-Aet al

doi: 10.1055/s-2006-957816 136 DengXZhaoJQuLDuanZFuRZhuCet al

206 Activation of the pro-apoptotic proteins recombinant Bak and Bax can insert into the mitochondrial membrane, causing changes in mitochondrial membrane permeability, loss of transmembrane potential, then releasing of Cyt c