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Other adverse effects include nephrotoxicity and gastrointestinal symptoms, which usually resolve with dose reduction or discontinuation [114, 115]

As an advantage, BiTE can link T cells and tumor cells without restriction to MHC and induce T cells' activation, proliferation, and cytotoxic function efficiently [105]

The recent discovery of the role of small RNAs in governing the epigenetic status of individual genes offers exciting new possibilities in therapeutics and chemoprevention