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10.1038/s41422-020-00441-1 149 TaoN.LiK.LiuJ.FanG.SunT

In GBM, elevated IDO1 expression correlates with tumor progression and poor prognosis, partly by suppressing ferroptosis via stabilizing SLC7A11 mRNA through FTO-dependent m6A methylation [89]

Now, inspired by the mitochondria-focused genetic interaction map in Saccharomyces cerevisiae 11 and the known influence of environment on genetic interactions 12 , we sought a dual genetic perturbation approach to probe the human SLC25 transporters under different metabolic states 13

The methionine loading results in an abnormal increase in homocysteinemia, revealing a defect in the transsulfuration pathway, which is attenuated by folic acid and/or pyridoxine supplementation

For example, some general antioxidants (e.g., vitamin C) may fail clinically by disrupting physiological redox signaling or acting as pro-oxidants at high concentrations