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Dynamin 2-dependent endocytosis sustains T-cell receptor signaling and drives metabolic reprogramming in T lymphocytes

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Immunomodulatory actionsincluding Nrf2 activation and NF-B suppressionare most consistently reported for isothiocyanates such as sulforaphane, which also possesses the strongest human pharmacokinetic dataset (peak plasma conjugate concentrations typically 0.one to two M