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Y., Ninomiya, H., Ohtani, K., Nagasawa, T

Cancer Biol Ther (2014) 15:141322

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Improved Membrane Permeability The cyclization of peptides contributes to the formation of intramolecular hydrogen bonds and the orientation of side chains, which in turn helps to protect polar atoms from solvent mediators, reduces intestinal, blood, and tissue degradation, decreases flexibility, reduces polar surface area, and facilitates the permeability of cell membranes

Patients should receive comprehensive education about proper injection technique, dose timing, storage requirements, and what to do if doses are missed