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(Thorpe et al., 2016) developed injectable thermally triggered hydrogel consisting of n-isopropylacrylamide (NIPAM) and dimethylacrylamide (DMAc)

In clinical trials, 12.3% of patients (10/81) with diabetes developed urinary retention following treatment with BOTOX 100 Units vs 0% of patients (0/69) treated with placebo

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(2014) Effect of erythropoietin and transfusion threshold on neurological recovery after traumatic brain injury: a randomized clinical trial

While its preclinical promise is undeniable, its path to becoming a widely accepted and approved therapeutic agent requires a concerted effort to generate robust human clinical data, address regulatory concerns, and precisely define its optimal applications