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Lipid-nanoparticle delivery of CRISPR/Cas9 in mouse germline models has demonstrated correction of infertility-linked alleles in mouse germline models, producing fertile offspring while maintaining genomic stability in follow-up generations [590]

In terms of sleep architecture, moderate doses of alcohol facilitate "rebounds" in rapid eye movement (REM) following suppression in REM and stage 1 sleep in the first half of an 8-hour sleep episode, REM and stage 1 sleep increase well beyond baseline in the second half

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