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Mancuso et al

On September 11, 2023, the Food and Drug Administration (FDA) announced its recommendation to shift to a monovalent coronavirus disease 2019 [COVID-19] vaccine that targets the predominant XBB lineage virus strain for the 2023-2024 vaccine administration season

I personally go for the 500mg dose because that is what I usually use and the difference between the two is 20p or 24p per serving so you get double dose for only 4p more per serving so makes economic sense too

Another stems from its sheer complexity

5-Amino-1MQ in research into adipose tissue metabolism Accelerated fat burning: Inhibition of NNMT leads to a reduction in 1-MNA levels (a product of NNMT activity), which promotes lipolysis the body is more inclined to mobilise fat stores