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Clinical and postmortem studies consistently demonstrate reduced BDNF expression and diminished neurogenic capacity in individuals with depression, while effective antidepressant treatments, including SSRIs, SNRIs, and electroconvulsive therapy, restore neurogenesis and promote neuronal maturation

Reduction in serum concentrations of uremic toxins driven by Bifidobacterium longum subsp

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Instead of being a protective shield against disease and infection, the immune system produces antibodies that kill the body's own cells, bringing pain, inflammation , and organ damage