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1993], leading to the activation of RAS

10.1146/annurev-pharmtox-010716-105001 Annu

Zhang et al, 2023a

These models permit researchers to understand how dysregulation of genes such as HHIP and FAM13A causes reduced lung regeneration and chronic inflammation, the main features of COPD [105, 106]

Beyond simple biomechanics, where each 1 kg of weight gain multiplies knee joint load by 34 kg, accelerating cartilage wear and activating pathogenic pathways like Wnt/ -catenin, the endocrine function of fat is paramount (14, 15)