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This may reflect a multi-spike phenomenon, whereby repeated exposures via vaccination and infection lead to direct toxicity, immune dysfunction, and pathological sequelae

Conventional treatments often provide limited results, leaving gaps in regeneration, inflammation control, and neurovascular healing

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*Correspondence: Mingxiu Li, [email protected]

This principle has led to the widespread practice of supplementing poultry diets with fat in hot climates, where the addition of fat helps increase dietary energy levels and reduce the detrimental impact of HS on bird performance