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Based on preclinical literature reviews, Pickart and colleagues proposed broader genomic effects, suggesting that, in sequencing models, GHK-Cu may influence approximately 31% of genes altered during skin aging, shifting expression patterns toward a younger phenotype [1]

Isik M, Eylem CC, Haciefendioglu T et al (2021) Mechanically robust hybrid hydrogels of photo-crosslinkable gelatin and laminin-mimetic peptide amphiphiles for neural induction

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Stability issues, particularly during long-term storage, and the limited availability of surfactants and cosurfactants further constrain their application [191]