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Annual review of immunology 34 , 173202, doi: 10.1146/annurev-immunol-041015-055539 (2016)

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Micronuclei can rupture and release genomic dsDNA into the cytosol, which is directly engaged by cGAS (113, 204)

The absence of human data means no established pharmacokinetics, safety profiles, dosing guidelines, or efficacy benchmarks exist for dihexa in any human population.