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GSH conjugation reactions with various chemotherapeutics contributing to the underlying chemoresistance should be taken into consideration in ongoing studies [113]

Although MSCs can be isolated from diverse tissuessuch as adipose tissue, bone marrow, umbilical cord, and dental pulptheir yield and proliferative capacity vary by source, and extensive in vitro expansion may alter their phenotype and potency [56,57,58]

Different studies have reported a wide variation in the prevalence of vitamin B12 deficiency in metformin users, with incidence ranging from 6% to 50%

George, Melkamu Tamir Hunegnaw, Ayse Zengin, Robin M

The effect, however, may be specific to this particular mammalian enzyme