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In heart failure models, TCM-derived metabolites often exhibit anti-remodeling effects: reducing hypertrophy, fibrosis, and improving calcium handling in cardiomyocytes

Picklo MJ, Idso JP, Jackson MI (2013) S-Glutathionylation of hepatic and visceral adipose proteins decreases in obese rats

404 Recent studies have reported that micro/nanomaterial-based artificial antigen-presenting cell platforms can induce T memory stem cells in vitro and sustain long-term T cell immunity, thereby providing durable immune competence in elderly individuals

In the case of inhaled materials, animal data have been taken from studies that consist of exposing rodents to chemicals in whole-body or nose-only systems, such as rodent acute (US EPA, 1998) inhalation toxicity studies from which no observed effect concentration (NOEC) or no observed adverse effect concentration (NOAEC) are derived to inform human health inhalation risk assessments ( In vivo studies have been used in risk assessment for many decades

According to another study, glutaminolysis increases the level of -KG production, resulting in GTP loading of RagB and lysosomal translocation of the mTORC1 complex in human cancer cell lines 160