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APAP challenge depleted intrahepatic GSH, to a similar extent, in both strain mice (Figure 1e)

(2025) reported that microglia exhibit region-specific increases and morphological alterations in response to combined MIA and repeated SDS stress (a two-hit mouse model, 2HIT)

Further optimization led to our next generation liver targeting PD-L1 small inhibitor, ALG-094103, which has similar in vitro potency to ALG-093702 with excellent oral bioavailability

doi: 10.3389/fmed.2025.1527051