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Pharmacotherapy is often necessary for treating patients with AWS to manage the symptoms of withdrawal, prevent the progression to serious complications, and bridge these patients to treatment for maintaining long-term recovery

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The HAS (French National Authority for Health) opinions are favorable, but negotiations between the CEPS (French Economic Committee for Health Products) and the pharmaceutical companies have not yet been finalized

Similarly, Acer2, downstream of HIF-2, also showed a sustained and stable increase after hypoxia at both protein and mRNA levels (Fig

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