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The external adverse elements, such as cigarette smoking, physical damage, and microbiota influence, may cause keratinocytes damaged through excessive production of ROS(Plenkowska et al., 2020)

Side-effect risk increases with improper dosing, contaminated material, or non-sterile injection technique

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Vitamin B12 injections (Hydroxocobalamin) are administered intramuscularly, generally into the top of the arm