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G., & Schene, A

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It works best in patients with a GH-axis contribution to their visceral fat burden

doi: 10.1016/j.biopha.2020.110036 100 TatematsuMTakahashiMFukushimaSHananouchiMShiraiT

Consistent with their opposing immune responses, M1-polarized macrophages undergo a large-scale metabolic rewriting, accompanied by various metabolite changes compared with M2 macrophages [76, 77], which can be summarized in the following categories: (1) Interrupted TCA cycle, upregulated PPP, and other alterations damage OXPHOS, triggering ROS production