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Metformin enhances GLUT1 expression and function in intestinal cells Previous studies have demonstrated that changes in glucose metabolism within the GI tract observed following gastric bypass surgery or metformin treatment are associated with alterations in the gene expression of glucose transporters 26,28,30,31,32

Accordingly, the lack of specificity and selectivity, together with bioavailability and safety problems, could be the main drawbacks of these approaches

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The treatment begins with a small blood draw, similar to a routine lab test