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doi: 10.3389/fmicb.2018.00757 186 StolfiCMarescaCMonteleoneGLaudisiF

Wearable sensors and smartphones now enable real-time symptom tracking, and ML algorithms can stratify patients for adaptive trial designs and biomarker discovery (Burchill et al., 2024

Specifically, the complex facilitates -ketoglutarates conversion to succinyl-CoA via decarboxylation, generating nicotinamide adenine dinucleotide (NADH) and flavin adenine dinucleotide (FADH2), thus fueling adenosine triphosphate (ATP) production in the mitochondria [2,19]

and 3) the activity of arginase [Citation17]

This suggests that a systemic decrease in NCOA4 can lead to an increase, rather than a decrease, in ferroptotic cell death