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Another mode of GSH depletion occurs through GSH transferase-mediated reactions where DEM, an electrophilic reagent and a mildly reactive alpha, unsaturated carbonyl compound conjugates with GSH which is catalyzed by GSH transferase which leads to the formation of hydrophilic GSH conjugates and causes rapid depletion of GSH [11, 92, 27] [90]

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The control values of 2 measured in the control subjects (Table 2) corresponded to the values of other investigators for the peptides of similar molecular weight, i.e

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68,69 However not all researchers have demonstrated an inverse association between vitamin B 12 status and metformin treatment as exemplified by one small study performed in Qatar