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When expressing URA3 heterozygously at the GSH1 locus, a loss of heterozygosity became evident over time under 5-FOA selection, likely attributable to mitotic crossovers

The delicate balance of the glyoxalase system and its modulation using GLO I inducers and inhibitors present compelling avenues for therapeutic interventions in diseases linked to dicarbonyl stress

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0.1% Tween-20), followed by 5 column volumes of wash buffer containing 1 mM ATP

Proteins such as Trx or Grx, which contain an attacking cysteine and a resolving cysteine (CxxC-motif), mediate the reduction of the disulfide