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8 It seems, reviewing the published literature and the LOVD (www.lovd.nl), and HGMD (www.hgmd.cf.ac.uk) databases, that clEDS is often caused by gene conversion events and this is the most common recurrent mechanism of pathogenicity

therefore, prescribers usually restrict use to adults unless compelling justification exists

& Toth, C

Beyond weight loss, early exploratory data suggest potential benefits including: Reductions in HbA1c (a marker of blood sugar control) in people with type 2 diabetes Improvements in lipid profiles (cholesterol and triglycerides) Reductions in liver fat, which may be relevant for metabolic dysfunction-associated steatotic liver disease (MASLD, formerly NAFLD), though these findings are preliminary Possible cardiovascular benefits

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