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The mechanisms behind B12 deficiency in metformin users are multifactorial but are probably related to intestinal absorption, so it seems sensible to assume that oral B12 replacement may be less effective, although there is little evidence in this area

Pharmaceutics 14:411

By Alaiyka Parvez Owner, CoLaz Aesthetics Clinic The short version It depends on the form: hydroxocobalamin is stored refrigerated at 2 to 8C, while cyanocobalamin is generally stable at room temperature

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Well, normally this vitamin is absorbed in the gut and so a disruption to normal gut function will reduce the amount of vitamin B12 that's being absorbed by the intestines and that will lead to a depletion of the normal body stores, which will then result in a deficiency in this vitamin within the body as a whole