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NICE notes that pernicious anaemia is the most common cause of Vitamin B12 deficiency in those aged 40-70, with an average onset age of 60 in white people and 50 in black people, although it can affect black women at a younger age

Within the hippocampus, astrocytes enriched in phosphoprotein enriched in astrocytes 15 (PEA15) are prominently represented, with PEA15 expression shown to increase progressively as astrocytes undergo maturation

doi: 10.1016/j.autrev.2008.08.003 228 HornigMGottschalkGPetersonDLKnoxKKSchultzAFEddyMLet al

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And that's where timing becomes critical