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Mechanisms underlying Nrf2 nuclear translocation by non-lethal levels of hydrogen peroxide: P38 MAPK-Dependent neutral sphingomyelinase2 membrane trafficking and ceramide/PKC/CK2 signaling

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J.G., Q.J., X.Z., and X.W

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We introduced our compounds into the lipoxygenase enzyme PDB ID: 3O8Y binding site 47

Despite nominal associations between higher neutrophil counts and exacerbators in the MGBB-KAS cohort ( p = 0.028) and lower FVC among exacerbators in the MGBB-LLF cohort ( p = 0.049), no clinical measures differed significantly between exacerbators and non-exacerbators across both cohorts (Fig