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It is estimated that approximately 70% of patients receiving chemotherapy develop CIPN during the first month of treatment [17, 20], whereas in approximately 2030% of these patients, CIPN might be converted to a chronic, persistent and highly pharmacoresistant form [17, 23] that can be observed 6 months or even longer after therapy cessation [14, 16, 27, 28]

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1,2 However, the literature is lacking with respect to defining the clinical needs of patients affected by the Rett Syndrome and there is no review available on the current therapeutic options

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Consistent with our previous findings, the upper section in Fig