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To date, isatuximab is the only clinically relevant anti-CD38 antibody shown to inhibit the catalytic activity of the enzyme (Table 2)

doi: 10.1093/molehr/gax032 45 PloutarchouPMeloPDayAJMilnerCMWilliamsSA

Really interesting findings and very aligned with what many of us are seeing

demonstrated that both basal and induced activity of transcription factor NF-E2-related factor 2 (Nrf2), a master regulator of antioxidant defense controlling a battery of antioxidant and detoxification genes, in maturing cortical neurons is extremely low due to epigenetic repression of the Nrf2 gene promoter 59

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