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LEACH, P.W., LENG, L.J., BELLAR, T.A., SIGSBY, J.E., & ALTSHULLER, A.P

This effect of ER activation is likely mediated by modulation of activity of a pathway projecting from the VMH to serotonergic neurons in the dorsal raphe nucleus a pathway important for the regulation of brown fat thermogenesis (BAT) and locomotor activity (83)

Research suggests that targeting ERR with DN200434 could overcome resistance to sorafenib by triggering ferroptosis, highlighting the potential role of estrogen-related receptors in regulating ferroptosis in cancer cells [98]