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In the study, participants with a responsive genetic score had an 82% increase in the likelihood of acheiving weight loss with a GLP-1 medication.[ref] Another study showed that GLP1 receptor variants are associated with greater weight loss on GLP-1 RA drugs.[ref] Common genetic variants in the GLP1R (GLP-1 receptor) gene impact weight and type 2 diabetes risk

Exceptionally: pneumothorax, accute respiratory failure requiring resuscitation

Glazer, C

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These drugs exert their effect by preventing the reabsorption of filtered glucose from the tubular lumen