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Moreover, ethyl amide derivatives, such as the potent antioxidant, L-NAC ethyl amide 59 , may have greater efficacy against fentanyl than L-NAC (m)ethyl esters based on greater resistance to desterfication by carboxylesterases 60

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Additionally, studies indicate that ketone infusion significantly reduces both glucose production and utilization, likely in terms of their inhibitory effects on gluconeogenesis and possible direct actions on hepatic glucose output [74]