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Description

Mechanisms of NAFLD development and therapeutic strategies

Preclinical studies in rodent models have evaluated outcomes such as fat oxidation, body-weight change patterns, and metabolic markers tied to fat breakdown and storage

Notable recent developments include the first preclinical study demonstrating NNMT inhibition improves cardiac function and reduces fibrosis in a heart failure model (Li et al., 2025), a comprehensive review of NNMT as a therapeutic target for neurodegenerative disorders (Liu et al., 2025), and emerging evidence that NNMT inhibition counteracts tubular senescence and fibrosis in chronic kidney disease