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Annals of the New York Academy of Sciences 669: 720

5.1 Relationship between migraine and oxidative stress 5.1.1 Clinical evidence of oxidative stress 5.1.1.1 Antioxidant capacity In contrast to the control group, patients with migraine without aura had higher total oxidative status (TOS), higher oxidative stress index (OSI), and lower total antioxidant status (TAS) (Jornayvaz and Shulman, 2010)

The mechanism is complementary: GHRP-6 signals the pituitary to release GH, while GHRH amplifies that signal and extends the duration of the pulse

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