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Cerebral ischemia leads to a decrease in ATP, which causes cellular apoptosis in the ischemic penumbra

Clearly, SAMes cellular functions are of direct relevance to the prevention of neurodegeneration and its depletion, as seen in the AD central nervous system, would be expected to carry widespread deleterious sequelae

A Comprehensive Study of Oxidative Stress in Tinnitus Patients

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Sporadic inclusion-body myositis: conformational multifactorial ageing-related degenerative muscle disease associated with proteasomal and lysosomal inhibition, endoplasmic reticulum stress, and accumulation of amyloid-42 oligomers and phosphorylated tau