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Furthermore, research indicates that CPS1, the key enzyme in the urea cycle, is predominantly expressed in hepatocytes and certain renal cells, with low or absent expression in most immune cells due to the urea cycles inactivity in these cells (134, 135)

The ICE-CBF-COR pathway in cold acclimation and AFPs in plants

10.1093/neuonc/nou358 73 OuR.LuS.WangL.WangY.LvM.LiT.et al (2022)

Brain Res 1983;275:321-8

Tryptophan deprivation results in diminished proteosynthesis and decreased activation of the rapamycin pathway, perhaps contributing to polyneuromyopathy [71]