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The finding that GSH can enter the ER by facilitated diffusion through the Sec61 translocon in a yeast mutant [36] is congruent with this model, even though it should be acknowledged that the toxic ~ 10-fold increase in cytosolic GSH in this yeast mutant represents a rather non-physiological situation with regard to glutathione gradients at intracellular membranes

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(35393970) [3] Ocular findings : Eyes that are squeezed shut (actual generalized status epilepticus patients should be unconscious and not resist eyelid raising)

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For complex multifactorial diseases such as autoimmune disorders, aOoC systems could facilitate the discovery of personalized biomarkers and therapeutic targets by recreating each patients unique genetic, epigenetic, and microenvironmental landscape