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[DOI] [PMC free article] [PubMed] [Google Scholar] 88.Silva K.C., Rosales M.A., Hamassaki D.E., Saito K.C., Faria A.M., Ribeiro P.A., Faria J.B., Faria J.M

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As understanding of oxidative stress in neurodegeneration deepens, current research is increasingly focusing on the mechanisms that drive GSH depletion and the broader implications of oxidative imbalance in the brain

Lead interferes with several steps of heme synthesis and inhibits aminolevulinic acid dehydratase (ALAD), an enzyme encoded by the ALAD gene that catalyzes the second step of porphyrin biosynthesis