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Studies that are published without peer-review and thereby miss the opportunity to subject the work to other experts for maintaining quality standards are also regarded as Level 1 studies

We demonstrate the applications of this probe of metabolism for kinetic characterization of the glyoxalase system in isolated cells as well as mouse brain, liver and lymphoma in vivo

doi:10.2174/1568026611313070006

Understanding that architectural difference multi-molecule combination versus multi-target single molecule is the key to understanding how these three relate and why a researcher might choose one over another