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Also, in PD patients, the nuclear localization of Nrf2 is strongly induced, but this response may not be sufficient to protect neurons from degeneration (Ramsey et al., 2007)

Neither deviation is dangerous at this early phase, but consistency matters over time

In the clinical setting, prolonged azole exposure in patients undergoing antifungal therapy may lead to the selection of resistant strains that persist despite treatment and continue to cause infection (Howard et al., 2009)

Research has also examined its potential roles in modulating gene expression associated with extracellular matrix remodelling