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After filtration and concentration, the obtained crude product was purified by chromatography on silica gel with petroleum ether/dichloromethane (1/1, v/v) to give a yellow solid product 19 (160 mg, 63%)

This was evidence by a decrease in skin lesions such as redness, hair loss, and ulceration, and these effects were confirmed via histopathological analysis

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Next, a fused macrophage and red blood cell membrane ([M+RBC]m) was used to camouflage PB@(PC+ART) NPs, yielding M@PB@(PC+ART) NPs, which enhanced NP recruitment to plaque regions and prolonged circulation time