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We run the GSH program and the APAP program together - they share the substrate GSH, which is drawn down by the overdose and replenished by the GSH synthesis pathway

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Moreover, Xia et al

Non-canonical pyroptosis is initiated by the detection of intracellular lipopolysaccharide (LPS) from Gram-negative bacteria, leading to the activation of caspase 4 (CASP4) and caspase 5 (CASP5) in humans and caspase 11 (CASP11) in mice, which cleave GSDMD independently of inflammasome assembly