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Their study revealed that Nrf2 regulates the expression of genes dependent on antioxidant response elements (ARE), which are essential for maintaining cellular resilience against oxidative stress

Veyrat-Durebex C, Reynier P, Procaccio V, Hergesheimer R, Corcia P, andres CR, et al

Although NAWM microglia exhibited state shifts, consistent with previous reports showing reactive microglia throughout the CNS in MS patients, changes were modest compared to the lesion tissues (Fig