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Abbreviations 5-HD: 5-hydroxydecanoate AMPK: AMP-activated protein kinase ETC: Electron transport chain G-6-P: Glucose-6-phosphate Glut-1: Glucose transporter 1 LPS: Lipopolysaccharide MnSOD: Manganese superoxide dismutase MRS: magnetic resonance spectrum mtDNA: Mitochondrial DNA nDNA: Nuclear DNA NO: nitric oxide NOS: nitrogen species NRF-1: Nuclear respiratory factor-1 NRF-1/2: nuclear respiratory factors 1 and 2 OXPHOS: Oxidative phosphorylation PGC-1: PRAR-coactivator-1 PMN: Polymorphonuclear neutrophil rhTFAM: Recombinant human TFAM ROS: Reactive oxygen species TFAM: Mitochondrial transcription factor A TPP: Triphenylphosphonium VDACs: Voltage dependent anion channels References Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, et al

Consistent with this, we observed that KEAP1NRF2 pathway inhibition curtailed the stemness features of chemoresistant MIBC cells, based on the findings that KEAP1 upregulation or NRF2 blockade significantly reduced tumor sphere formation, clonogenic growth and invasiveness, hallmarks of the stem cell-like, therapy-tolerant state

Crews CM, Mohan R

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Consult with a healthcare provider to determine the best approach for your individual needs