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To account for this variability and possible differences in secretion due to gland size, saliva secretion measurements are reported as saliva weight/gland weight as previously reported 51 , assuming a saliva density of 1.0 g/mL 56

Cancer cells in tumors with IDH1 or IDH2 mutations show oncogenic activity by converting glutamine-derived -KG to 2-hydroxyglutarate (2-HG), which competitively inhibits -KG-dependent histone and DNA modification enzymes 27

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We liked the fact that it can also increase intracellular levels of glutathione by over 10% within seven hours

Glutamate is then converted into -KG, which enters the process of TCA cycle anaplerosis either by transaminase or GDH and generates non-essential amino acids, such as alanine and aspartic acid (46)