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Two decades later, Kovalzon and Strekalova (2006) [6] were equally direct, calling DSIP a still unresolved riddle and noting that the connection between the peptide and sleep has never been further characterized, in part because of the lack of isolation of the DSIP gene, protein and possible related receptor. That framing has not materially changed in the literature since

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However, recent clinical trials have demonstrated that the positive effect of these PPIs is primarily restricted to the upper gastrointestinal tract