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Malar J 16, 361 (2017).

Notably, these compounds interact with multiple key pathogenic pathways implicated in AKI, including cell adhesion molecules (CAMs), Shh signaling, JAK/STAT cascades, purinergic P2X7 receptors, heat-shock proteins (Hsps), and PI3K/Akt/mTOR signaling networks

BiMix : Contains Papaverine and Phentolamine, used for patients who may be sensitive to Alprostadil or who experience side effects from it, such as a painful erection

a "co-stimulatory molecule refers to the cognate binding partner on a T cell that specifically binds with a co-stimulatory ligand, thereby mediating a co- stimulatory response by the T cell, such as, but not limited to, proliferation

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